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| Claude Rains | Dr. Jack Griffin aka The Invisible Man | |
| Gloria Stuart | Flora Cranley | |
| William Harrigan | Dr. Arthur Kemp | |
| Henry Travers | Dr. Cranley | |
| Una O'Connor | Jenny Hall | |
| Forrester Harvey | Herbert Hall | |
| Holmes Herbert | Chief of Police | |
| E.E. Clive | Constable Jaffers | |
| Dudley Digges | Chief Detective | |
| Harry Stubbs | Inspector Bird | |
| Donald Stuart | Inspector Lane | |
| Merle Tottenham | Millie | |
| Robert Adair | Detective Thompson | |
| Edgar Barrier | Radio Announcer | |
| Ted Billings | Villager Playing Darts |
| Director |
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| Producer |
Carl Laemmle Jr.
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| Writer |
H.G. Wells
R.C. Sherriff |
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| Cinematography |
Arthur Edeson
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| Musician |
Heinz Roemheld
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After experimenting on himself and becoming invisible, scientist Jack Griffin, now aggressive due to the drug's effects, seeks a way to reverse the experiment at any cost. |
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